Objectives : The purpose of this study wa:> to evaluate the effect of alcohol on sedation and some cognitive function(eg, daytime sleepiness, fatigue, and mood measured by multiple sleep latency test(MSLT) anci visual analogue scale (VAS), vigilance, attention anci short-term memory measured by Vienna Test System).
Methods : 15 healthy, normal young college students participated in this study. Participating subjects were in good phy::ical and psychological health and were asymptomatic as to sleep/wake complaints. Subjects visited our laboratory by 08:00 at the first day, and they had baseline MSLT and Test(at 9 ; 00, 11 ; 00, 14:00, and 16:00). Each time, the subjects completed VAS for sleepiness, fatigue and mood before they underwent an Vienna Test to evaluate their vigilance, attention and short-term memory. On the second day, subjects had 0.5g/kg of alcohol, the third day, subjects had 1.Og/kg of alcohol, and repeated the same process as those of the first.
Results : 0.5g/kg of alcohol reduced sleep latency after 1 hour, and 1.Og/kg of alcohol reduced sleep latency until 5 hours after administration significantly. 0.5g/kg of alcohol induced daytime sleepiness 1 hour after administration, ar~d 1.Og/Icg of alcohol induced daytime sleepiness and fatigue until 3 hours after administration, but there were no effects on mood. Vigilance was decreased significantly 1 hour after 0.5g/kg of alcohol administration, and attention and short--term memory were not changed significantly after alcohol administration. After alcohol administration(0.5-1.Og/kg), there were significant positive correl~ition between daytime sleepiness and fatigue, and fatigue and mood.
Conclusion : It can be concluded that alcohol decreases sleep latency and induces daytime sleepiness and fatigue, acid decreases vigilance in normal subjects.
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